尿微量白蛋白检测在哮喘急性重度发作期肾损害的诊断价值

Diagnostic Value of Uninary Trace Albumin Test on the Early Impairment of the Kidney in Acute Severe Exacerbation of Asthma

目的探讨尿微量白蛋白检测在哮喘急性重度发作期肾损害的诊断价值。方法收集34例急性重度发作期、缓解期患者晨尿、空腹静脉血,采用酶联免疫测定法测定尿微量白蛋白,并测定肌酐(Cr)、血尿素氮(BUN)。结果哮喘患者在急性重度发作期尿微量白蛋白较正常对照及缓解期显著性升高(P<0.05),重度急性发作期Cr及BUN无明显改变(P>0.05)。结论尿微量蛋白在急性重度发作期肾功能受损时较肾功能指标Cr,BUN改变出现早,是诊断肾功能早期损害的敏感指标。

Objective To probe diagnostic value of uninary trace albumin test on the early impairment of the kidney function in acute severe exacerbation of asthma. Methods To collect morning urine and intravenous blood specimenof thirty-four asthma patients, when they were in the severe exacerbation and in alleviation peried, to test the uninary trace albumin with ELISA, and serum Cr, BUN And 24 healthy volunteer as contrl. Results The asthmatic patients uninary trace albumin were obviously higher than that in the normal alleviational period （P〈0.05）, which Cr and BUN did not have obvious changes compared with in the normal and alleviational period （P〉0.05）. Conclusion Uninary trace ablumin appear earlier changes than that of kidney function of Cr and BUN in the acute severe asthma exacerbation. It is a sensitive marker for the early impairment of kidney function diagnose.