丹参对犬冠脉结扎性心肌缺血生化指标的影响

Effects of Danshen Glucose Injection on the Biochemical Indexes in Dogs by Coronary Artery Ligation

目的:观察丹参葡萄糖注射液(以下简称丹参)静脉滴注对犬冠脉结扎急性心肌缺血模型血清生化指标的影响。方法:采用冠脉结扎法建立犬急性心肌缺血模型,测定给药前及给药后30min、45min、60min、120min、180min动脉血乳酸脱氢酶(LDH)、肌酸磷酸激酶(CPK),静脉血乳酸(LD)、游离脂肪酸(NEFA)、超氧化物歧化酶(SOD)及丙二醛(MDA)含量。结果:丹参高、低剂量组(3.2g/kg,0.8g/kg)可明显降低心肌缺血后的血清CPK和LDH活力,升高SOD,减少血中LD、NEFA、MDA含量。结论:丹参对冠状动脉结扎心肌缺血具有明显的保护作用。

Objective：To investigate the effects of Danshen glucose injection on the biochemical indexes in dogs coronary artery ligation. Methods：The acute myocardial ischemia model was established in dogs by ligation of coronary artery. The serum concentrations of LDH, CPK, LD, NEFA, SOD, MDA were detected before the administration of Danshen and after 30, 45, 60, 120, 180 minutes of administration respectively. Results： Danshen （ 3.2g/kg, O. 8g/kg ） can significantly decrease the activity of CPK and LDK, reduce the content of LD, NEFA, MDA and increase the level of SOD, Conclusion：Danshen glucose injection can protect myocardium against the acute ischemia induced injury in dogs.