美托洛尔治疗冠心病室性早搏临床研究

The Clinical Research of Metoprolol for Ventricular Premature Beat due to Coronary Heart Disease

目的研究美托洛尔治疗冠心病室性早搏的临床疗效。方法对84例冠心病(CHD)有室性早搏的病人随机分为治疗组和对照组,治疗组给予美托洛尔片12.5mgBid,逐步增加到50mgBid,对照组给予基础治疗。用药前及用药后2周分别作心脏彩超、X光胸片、心电图、24小时动态心电图检查,观察室性早搏、心脏左室射血分数、QTcd变化、统计学处理。结果治疗组室性早搏明显减少;治疗组QTcd缩短,治疗前治疗后比较差异有显著性(P<0.01),与对照组治疗后比较,差异有显著性(P<0.01)。结论美托洛尔对冠心病室性早搏有明显疗效,安全。

Objective To study the clinical curative effect of Metoprolol for the ventricular premature beat due to coronary heart disease. Methods 84 cases with coronary heart disease and ventricular premature beat were divided into experimental group and control group randomly. The experimental group was given Metoprolol 12.5rag twice every day and up to 50mg step by step, The control group were given basic treatment. Have heart color B-us, thorax x-ray, electrecardiography, 24-hours dynamic electrocardiography before and two wee, ks after having Metoprolol to observe the change of ventricular premature beat, left vertricular ejection fraction,QTcd. Analysis the data with statistics Results In the experimental group the ventricular premature beat were reduced markedly, QTcd were shorten. There have significant difference before and after the treatment（P〈 0.01）, contrast with the control group there also have significant difference （P〈0.01）. Conclusions Metoprolol markedly effect for ventricular premature beat due to coronary heart disease.