摘要
目的:观察枸杞多糖(LBP)对Ⅱ型糖尿病大鼠肾脏的保护作用及机制。方法:用链脲佐菌素(STZ)结合高脂饲料建立Ⅱ型糖尿病大鼠模型,根据胰岛素敏感指数、糖耐量曲线下面积分为模型组,LBP低、中、高剂量组[20、40、80mg/(kgbw?d)],同时设立正常对照及正常高剂量对照组,试验期1个月。检测LBP对Ⅱ型糖尿病大鼠血清糖基化终产物-肽(AGEs-P)、糖基化血红蛋白(HbAlc)及肾脏白介素-8(IL-8)含量、肾脏病理变化的影响。结果:LBP可降低Ⅱ型糖尿病模型大鼠血清AGEs-P及血浆HbAlc与肾脏中IL-8含量,肾脏病变明显改善。结论:LBP可降低模型大鼠糖基化终产物的产生,减少肾脏IL-8的分泌,从而预防糖尿病肾病的发生。
Objective. To study the protective effect of Lycium babarum polysaccharides （LBP） on kidney in type II diabetic rats and its mechanism. Method： The animal model of type Ⅱ diabetes was established by injecting streptozotocin combined with feeding high-lipid ration to SD rats. According to serum insulin , the insulin sensitivity index （ISI） and the area under the curve of glucose tolerance, the model rats were divided into four groups, including model group, LBP low, medium and high dose groups [20, 40, 80 mg/（kg bw. d）]. At the same time, normal control group and normal LBP high dose group were alloted. The levels of advanced glycosylation endproducts-peptide （AGEs-P） in serum, hemoglobin Alc （HbAlc） in plasma, and interleukin-8 （IL-8） in renal cortex were detected after given LBP for 1 month. The histopathological picture of kidney was also observed. Results： Serum AGEs level, plasma HbAlc level and IL-8 secretion after given LBP in diabetic rats were reduced, and the kidney lesion was ameliorated. Conclusion： LBP can prevent diabetic nephropathy by reducing AGEs and the secretion of IL-8 in kidney of type Ⅱ diabetic rats. [ACTA NUTRIMENTA SINICA, 2006, 28（1）： 47-50]
出处
《营养学报》
CAS
CSCD
北大核心
2006年第1期47-50,共4页
Acta Nutrimenta Sinica
基金
南京市科技局社会发展基金(No.200301093-2)
关键词
枸杞多糖
糖尿病肾病
糖基化终产物
白细胞介素-8
Lycium barbarum polysaccharide （LBP）
diabetic nephropathy
advanced glycosylation endproducts-peptide （AGEs-P）
interleukin-8 （IL-8）
