分子再吸附循环系统治疗重型肝炎20例疗效观察

Observation on effects of treatments using molecular adsorbent r ecirculating system (MARS) in 20 patients with severe hepatitis.

目的探讨分子吸附再循环系统(MARS)治疗重型肝炎的疗效和安全性。方法对20例慢性乙型重型肝炎患者在内科综合治疗基础上,使用分子吸附再循环系统支持治疗,每次6h。结果20例患者经MARS人工肝治疗后,治愈好转12例,治愈好转率60%;血中总胆红素、胆汁酸等非水溶性蛋白结合毒素及血氨等水溶性毒素明显下降(P<0.05),凝血酶原活动度显著升高(P<0.05),治疗前后肾功能、血常规和电解质无显著变化(P>0.05);治疗期间血压、心率稳定。结论MARS是临床治疗重型肝炎安全有效的方法。

Objective To explore the effect and safety of molecular adsorbent recirculating system （MAILS） on patients with severe hepatitis B. Methods 20 patients with chronic severe hepatitis were treated with MAILS for 6 to 8 hours except for basic medical therapy. Results After MARS, 12 of 20 patients have been cured and improved, the survival rate was 60% .Total bilirobin, total bile acids et al, and concentration of serum ammonia decreased significantly, while prothrombin activity was signicantly increased （P 〈 0.05） . No significant difference was observed in renal function, blood routine test and electrolure before and after MARS （ P 〉 0.05）, and all patients had stable blood pressure （BP） and pulse （P） during the treatment of MARS. Conclusion MARS is an effeetive and safe means to treat severe hepatitis.