阵发性房颤患者血中纤维化指标的水平及意义

Serum levels and clinical significances of fibrosis markers in patients with paroxysmal atrial fibrillation

目的研究阵发性房颤患者血中纤维化指标的水平及意义。方法60例阵发性房颤患者及60例正常对照组分别测定血清Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、透明质酸(HA)和层黏连蛋白(LN)并进行组间比较。结果阵发性房颤组血清中PCⅢ、CIV、HA及LN水平分别为(156.1±10.5)μg/L(、119.6±11.5)μg/L(、126.3±10.0)μg/L(、127.5±7.3)μg/L,明显高于正常对照组[(88.6±11.3)μg/L、(71.6±11.0)μg/L、(69.6±9.7)μg/L(、97.9±6.8)μg/L],均P<0.05。结论阵发性房颤患者血清中纤维化指标水平增高,提示阵发性房颤患者存在心房间质的纤维化。

Objective To evaluate the serum levels of fibrosis markers and clinical significance in patients with paroxysmal atrial fibrillation. Methods Sixty patients with paroxysmal atrial fibrillation and 60 normal controls were enrolled. The serum type Ⅲ procollagen（PCⅢ）, type Ⅵ collagen（CⅥ）, hyaluronic acid（HA） and laminin（LN） were measured and compared between two groups. Results The concentrations of serum PCⅢ, CⅥ, HA and LN, respectively （156.15± 10.5） μg/L, （119.6 4± 11.5） μg/L, （126.3 ±10.0） μg/L, （127.5 4± 7.3） μg/L in paroxysmal atrial fibriⅡation group, were significantly higher than those in normal controls, respectively （88.6 4±11.3）μg/L, （71.6 d：Ⅱ.0） /μg/L,（69. 64±9. 7） /μg/L,（97.94±6.8） /μg/L（all P 〈0.05）. Conclusion The levels of serum Pen, CⅥ, HA and LN increase in the patients with paroxysmal atrial fibriLLation. These results indicate that fibrosis may take place in atrial interstitium of the patients.