针刺对肺癌手术患者肿瘤坏死因子的调节作用

Regulative Effect of Acupuncture on Tumor Necrosis Factor(TNF)in Patients with Lung Cancer Operation

目的探讨肺癌手术患者应用针刺提高免疫功能研究对肿瘤坏死因子(tumornecrosisfactor,TNF)的调节作用。方法采用双抗体夹心免疫酶标法(enzymelinkedimmunosorbentassay,ELISA)检测肺癌患者血清中肿瘤坏死因子含量;针药麻组与全麻组肺癌手术患者各30例,分别在术前、术后第8日、术后第12日测量TNF含量作比较。结果血清中肿瘤坏死因子含量在术前作两组比较(P>0.05)无明显差异;在术后第8日及术后第12日作比较(P<0.05)均有显著差异,针药麻组明显优于全麻组。结论针刺能提高肺癌手术患者血清中肿瘤坏死因子含量,对肺癌手术患者有免疫调节功能。

Objective To investigate the regulative effect of acupuncture-improved immunological function on tumor necrosis factor （TNF） in patients with lung cancer operation. Methods The tumor necrosis factor content of serum was measured by double-antibody enzyme linked immunosorbentassay. TNF content was measured before operation and at 8 days and 12 days postoperatively in 30 patients with lung cancer operatioin under acupuncture-drug anesthesia and 30 patients with lung cancer operation under general anesthesia and compared between the two groups. Results There was no significant difference in serum tumor necrosis factor content before operation （ P 〉 0.05 ） but there were at hoth 8 days and 12 days postoperatively （ P 〈 0.05 ） between the two groups. The effect was significantly better in acupuncture-drug anesthesia group than in the general anesthesia group. Conclusion Acupuncture can increase the tumor necrosis factor content of serum and has a regulative effect on immunological function in patients with lung cancer operation.