血清抗心磷脂抗体与系统性红斑狼疮肾小球微血栓形成之间的关系

Research of Relationship of Anticardilipin antibodies and Glomerular Capillary Thrombosis in Patients with Systemic Lupus Erythematosus

目的探讨系统性红斑狼疮(SLE)患者血清抗心磷脂抗体(ACA)与其他致病抗体、临床表现、疾病活动性、生化指标及肾小球毛细血管血栓形成之间的关系。方法采用 ELISA 法检测36例 SLE 患者和30例健康对照者血清 ACA,并分析 SLE 患者的临床表现、实验室指标及肾小球毛细血管病理改变与 ACA 的关系。结果 36例 SLE 患者中,ACA 阳性率显著高于健康对照组(P＜0.001)。肾活检病理结果显示,ACA 阳性组肾小球毛细血管血栓的发生率高达59%,而阴性组仅为 14%,两组肾小球血栓发生率比较差异有显著性(X^2=3.96,P＜0.05)。结论 SLE 患者血清 ACA 可能参与 SLE 肾小球微血栓形成、关节免疫性炎症反应及其他系统炎症损害的机理。

Objective To study the relationship between anticardilipin antibodies （ACA） and other pathogenic antibodies, clinical manifestation,biochemical indicators and glomerular capillary thrombosis in patients with systemic lupus erythematosus （SLE）. Methods The enzyme-linked immunosorbent assay （ELISA） was used to measure the ACA in serum of 36 SLE patients and 30 healthy contors. We analysised the clinical menifestations, laboratory indexes and glomerular capillary pathological changes in patients of SLE. Results The positive ACA of the 36 SLE patients was significantly higher than those of healthy controls （P 〈 0. 001 ）. Renal biopsy pathology, the incidence rate of glomerular capillary thrombosis was 59% in ACA positive ,while 14% in ACA negative. There was significant difference in two sets（ x^2 = 3.96, P 〈 0. 005 ）. Conclusion ACA in SLE patients may take part in glomerular capillary thrombosis, articulation immunity inf- amation reaction and other immunity mechanisms.