摘要
目的采用血栓弹性描记仪研究结肠癌患者围术期间凝血功能的改变。方法择期行手术治疗的结肠癌患者40例,应用血栓弹性描记仪检测麻醉前5 min(T_0),手术开始后30 min(T_1),手术开始后2h(T_2),手术结束后2 h(T_3) 血栓弹力图(TEG)参数反应时间(R)、凝血时间(K),α角(ANG)和最大振幅(MA)的改变。对照组为20例健康志愿者。结果与正常对照组比较,结肠癌患者 R 明显缩短(P<0.05),ANG 和 MA 明显增大(P<0.01)。晚期患者的 ANG 和 MA 大于早期患者(P<0.05),手术期间 T_2与 T_0比较,ANG 和 MA 明显增大(P<0.05)。结论结肠癌患者存在血液的高凝状态,而手术与创伤应激可进一步增加血液的高凝程度。
Objective To study coagulation of colon cancer patients in perioperative period by thrombelastography analyzer. Methods Thrombelastography variables( R, K, ANG, MA) was measured in 40 cases patients with colon cancer before anesthesia(T0),30 rain after operation begining(T1) ,2 h after operation begining(T2) and 2 h after operation (T3). The control group consists of 20 healthy volunteers. Results In colon cancer group ,ANG and MA were larger than normal group( P 〈 0. 01 ) ,and R was shorter than normal group( P 〈0. 05). ANG and MA in the patients of terminal phase were lager than early phase(P 〈0. 05). ANG and MA at T2 were lager than that at To (P 〈 0. 05). Conclusion Colon cancer patients have sthenic coagulation function originally which can be aggraveted by the stress of operation trauma.
出处
《血栓与止血学》
2006年第1期21-23,33,共4页
Chinese Journal of Thrombosis and Hemostasis