高压氧对冠状动脉支架术后患者von Willebrand因子和纤维结合蛋白的影响

Efects of Hyperbaric Oxygen Therapy on the Level of von Willebrand Factor and Fibronectin in Patients with Intracoronary Stenting

目的了解高压氧治疗对冠状动脉(冠脉)支架术后患者von Willebrand因子(vWF)和纤维结合蛋白(Fn)的影响。方法对64例首次接受冠脉内支架治疗的冠心病患者随机分为高压氧治疗组和对照组,比较治疗前血清vWF和Fn的测定结果。结果高压氧组在治疗后vWF及Fn含量均显著低于治疗前(P<0.05),而对照组治疗前后vWF及Fn含量的差异均无显著性改变(P>0.05)。治疗前两组的vWF及Fn含量差异均无显著性(P>0.05),而治疗后两组vWF及Fn含量差异均有显著意义(P<0.05)。结论高压氧治疗可显著降低冠脉支架术后患者血清vWF及Fn的含量。

Objective To study the effects of hyperbaric oxygen therapy on the level of von Willebrand factor（vWF） and fibronectin（Fn） in patients with intraeoronary stenting. Methods 64 patients with successful stenting implatation were randomly divided into 2 groups（hyperbaric oxygen group and the control group）, the level of vWF and Fn before and after treatment were compared between 2 groups. Results The level of vWF and Fn were significantly decreased in the tested group after treatment （ P 〈 0.05）, The level of vWF and Fn in the tested group were significantly less than that in control group after treatment（ P 〈 0.05）. Conclusion The therapy of hyperbaric oxygen therapy can significantly decreased the level of vWF and Fn in patients with intmcoronary stenting.