抑郁症患者睡眠障碍的研究

The studys on the sleep disorders of depression patients.

目的观察抑郁症患者的睡眠障碍是否具有特异性，这对单纯性睡眠障碍与抑郁症睡眠障碍的鉴别，抑郁综合征的诊断和治疗都有明显的意义。笔者着重探讨抑郁症患者睡眠行为与单纯性睡眠障碍患者睡眠行为的关系，为临床治疗提供一定的帮助。方法对26例抑郁症患者，和20例单纯性睡眠障碍的睡眠行为进行研究，同时对全部被研究者进行多导睡眠图检测，以观察睡眠生理的改变。结果（1）抑郁症组的入睡困难，早醒。睡眠维持障碍的发生率高于对照组（P〈0．05，P〈0．01）；（2）抑郁症组存在睡眠潜伏期长[（38．3±18．0）min]觉醒时间、觉醒次数、醒觉睡眠比，睡眠效率和睡眠维持率低（P〈0．05，P〈0．01），快速眼动睡眠潜伏期短[（62．6±30．8）min]等。（3）对照组主要是浅睡期时间短，整个睡眠周期缩短但睡眠周期完整，无明显特异性。结论抑郁症患者存在睡眠行为与睡眠生理的异常改变，其睡眠障碍的病理机制可能与抑郁症的发病机制有一定关系。

objective Whether the obstacle of sleep in depressed patients has the particularity or not. It has the obvious help to the diagnosis and treatments this synthesize. To explore the behavioral and physiologic changes of sleep in the depressive patients. Methods Sleep behavior and all night polysomnographic recordings were performed in 26 depressed patients and 20 Pure obstacle of sleep. Results （1） Compared with other, the incidences of sleep continuity disturbance, early awake, hypersomnia and difficulty falling asleep in depressed patients group were signi - ficant increased （P 〈 0.05, P 〈 0.01）. （2） REM latency was shorter in depressed patients than that in Matched control; and slow wave sleep, sleep efficiency, sleep maintenance in patient group were markedly decreased （P 〈 0.05, P 〈 0.01） ; while the awake duration, arousal times, sleep stage, rate of awake/asleep were increased in patient group （P 〈 0.05, P 〈 0.01）. RL were increased in patient group [ （62.64 ± 30.8） min ]. （3） Other in comparison group was shorter in NREM. The period of sleep is increased but integrity. It＇s no particularity.Conclusions It is consistent the behavioral disorders of sleep with the physiologic dysfunction in depression, and the pathogenesis of sleep distur bance may result from the etiology of depression.