摘要
To investigate the effect of magnesium sulfate on the fetal rats of FGR and the expression of caspase-3 in the placenta of maternal rat ; To explore the mechanism of using magnesium sulfate to cure the FGR. Establish model of FGR by a way of passive smoking： giving the maternal rats different agent of magnesium sulfate by subcutaneous injection： low agent group （300 mg/kg）, high agent group （600 mg/kg）. Concentration of magnesium sulfate was monitored. The expression of caspase-3 was measured by RT-PCR and immunohistochemistry technology. Both of the concentrations of magnesium sulfate in high and low agents group are higher than the FGR group （P〈0.01）;the weight of the placenta and fetal rat in high agent group are higher than the FGR group （P〈0.05 and P〈0. 01） ; the expression of mRNA and protein of caspase-3 in the two agent group is higher than the FGR group （P〈0.05 respectively） ; concentration of magnesium sulfate in the maternal rat blood correlate to the weight of fetal rat （r=0. 899, P=0. 038） and the expression of caspase-3 in the placenta of maternal rat （r=-0. 747, P=0. 033; r=-0. 915, P=0. 001）. The research suggests that the weight of fetal rat could be increased by treatment of magnesium sulfate. Because it would imfrmove the placental function by depressing the expression of caspase-3.
To investigate the effect of magnesium sulfate on the fetal rats of FGR and the expression of caspase-3 in the placenta of maternal rat ; To explore the mechanism of using magnesium sulfate to cure the FGR. Establish model of FGR by a way of passive smoking： giving the maternal rats different agent of magnesium sulfate by subcutaneous injection： low agent group （300 mg/kg）, high agent group （600 mg/kg）. Concentration of magnesium sulfate was monitored. The expression of caspase-3 was measured by RT-PCR and immunohistochemistry technology. Both of the concentrations of magnesium sulfate in high and low agents group are higher than the FGR group （P〈0.01）;the weight of the placenta and fetal rat in high agent group are higher than the FGR group （P〈0.05 and P〈0. 01） ; the expression of mRNA and protein of caspase-3 in the two agent group is higher than the FGR group （P〈0.05 respectively） ; concentration of magnesium sulfate in the maternal rat blood correlate to the weight of fetal rat （r=0. 899, P=0. 038） and the expression of caspase-3 in the placenta of maternal rat （r=-0. 747, P=0. 033; r=-0. 915, P=0. 001）. The research suggests that the weight of fetal rat could be increased by treatment of magnesium sulfate. Because it would imfrmove the placental function by depressing the expression of caspase-3.
