单频准分子光治疗白癜风的临床研究

Treatment of vitiligo with the monochromatic excimer light 308-nm

目的研究观察单频准分子光308nm局部照射治疗白癜风的临床疗效,评估其安全性。方法对77例不同临床类型的白癜风患者的201处皮损进行局部照射,每周1次,随访3￣6个月。结果经过准分子光局部照射平均18次,86.6%皮损有不同程度色素恢复,色素恢复随疗程延长而增加,照射24次总有效率为71.0%,显效率为51.6%。躯干、颈部和头面部疗效优于四肢及手足;泛发型和节段型白癜风疗效尤佳。主要不良反应为局部水疱和疼痛,患者能耐受。结论准分子光局部照射治疗白癜风疗效显著,且不良反应少。

Objective To evaluate the efficacy and tolerance of monochromatic excimer light （MEL） 308 nm in the treatment of vitiligo. Methods Seventy-seven patients were enrolled in the prospective and open clinical study. Two-hundred and one lesions were subjected to local phototherapy of MEL 308-nm once a week for 3 to 6 months. Results Of these lesions, 86.6% obtained repigmentation at different degrees. The repigmentation was more obvious in lesions on the head, face, neck and trunk than in those on the limbs or extremities. Moreover, patients with generalized and segmental vitiligo got a better improvement than patients with other types of vitiligo. Conclusion MEL 308-nm is effective in the treatment of vitiligo without obvious adverse effects.