NP63在涎腺上皮性肿瘤中的表达

Expression of ΔNp63 in Salivary Gland Tumours

目的研究ΔNP63在涎腺上皮性肿瘤的表达分布情况,探讨ΔNP63在涎腺上皮性肿瘤发生发展、侵袭转移及鉴别诊断中的意义。方法收集经华西口腔医院病理科病理确诊为涎腺上皮性肿瘤的病例68例,组织切片常规HE染色和免疫组化染色(SP法)。结果ΔNP63表达于涎腺上皮性肿瘤肌上皮样细胞和基底细胞样细胞,ΔNP63在良恶性肿瘤中的表达有差别(P<0.05),恶性肿瘤表达强于良性肿瘤。结论ΔNP63在促进癌细胞增殖与去分化中可能具有一定作用,提示ΔNP63具有一定的原癌基因活性。ΔNP63是良好的肌上皮细胞标记物,与不同指标的联合使用,为涎腺肿瘤鉴别诊断提供一个新的指标,具有一定的临床应用价值。

Objective To detect the expression of △Np63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors. Methods Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain. Results It was found that the expression of △Np63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of △Np63 is correlated directly with benign and malignant tumor. Conclusion △Np63 plays an important role in salivary gland tumours. △Np63 possesses some special activity that is characteristic of oncogene, p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis, p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.