肾脏生理基础研究进展对临床工作者的启示被引量：2

导出

摘要生命科学基础研究日新月异的进展。已经使很多传统的概念发生重大改变。这就促使我们临床工作者在十分繁忙的临床实践中面临着知识更新的课题。笔者认为只有密切关注这些主要进展。不断与临床实践相结合才能提高临床诊治水平。下面就与肾脏生理有关的小球滤过、小管离子转运以及内分泌功能等3方面举例说明。

作者林善锬

机构地区复旦大学附属华山医院肾脏科

出处《中华肾脏病杂志》 CAS CSCD 北大核心 2006年第1期1-4,共4页 Chinese Journal of Nephrology

关键词生理基础研究临床工作者肾脏生理临床诊治水平临床实践内分泌功能生命科学知识更新离子转运

参考文献18

1Haraldsson B,Sorensson J.Why do we not all have proteinuria? an update of our current understanding of the glomerular barrier.News Physiol Sci,2004,19:7-10.
2Saleem MA Ni,L,Witherden L,Tryggvason K,et al.Colocalization of nephrin,podocin,and the actin cytoskeleton evidence for a role in podocyte foot process formation.Am J Pathol,2002,161:1459-1466.
3Pavenstadt H,Kriz W,Kretzler M.Cell biology of the glomerular podocyte.Physiol Rev,2003,83:253-307.
4Schwars K,Simons M,Reiser J,et al.Podocin,a raftassociated component of the glomerular slit diaphragm,interacts with CD2AP and nephrin.J Clin Invest,2001:108:1621-1629.
5Benzing T.Signaling at the slit diaphragm.J Am Soc Nephrol,2004,15:1382-1391.
6Coward RJ,Foster RR,Pattern D,et al.Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin,podocin,and CD2associated protein in cultured human podocytes.J Am Soc Nephrol,2005,16:629-637.
7Meyrier A.Mechanisms of disease:focal segmental glomerulosclerosis.Nat Clin Pract Nephrol,2005,1:44.
8Garty H,Palmer LG.Epithelial sodium channels:function,structure,and regulation.Physiol Rev,1997,77:359-396.
9McDonald FJ,Western AH,McNeil JD,et al.Ubiquitinprotein ligase WWP2 binds to and downregulates the epithelial Na+channel.Am J Physiol Renal Physiol,2002,283:F431-F436.
10Dahlmann A,Pradervand S,Hummler E,et al.Mineralocorticoid regulation of epithelial Na+channels is maintained in a mouse model of Liddle's syndrome.Am J Physiol Renal Physiol,2003,285:F310-F318.

1王海燕.循证医学在我国肾脏病学科发展中的应用现状与展望[J].中华肾脏病杂志,2007,23(3):137-139. 被引量：11
2黎磊石,刘志红.肾小球疾病免疫抑制剂治疗的新方向——多靶点免疫抑制治疗[J].肾脏病与透析肾移植杂志,2007,16(1):3-4. 被引量：35
3Nishie T, Miyaishi O, Azuma H, et al. Development of immunoglobulin A nephropathy- like disease in beta-1, 4- galactosyltransferase-Ⅰ-deficient mice. Am J Pathol, 2007, 170: 447-456.
4Chen X, Qiu Q, Tang L, et al. Effects of co-administration of urokinase and benazepril on severe IgA nephropathy. Nephrol Dial Transplant,2004,19 : 852-857.
5Dickler HB, Fang D, Heinig SJ, et al. New physician- investigators receiving National Institutes of Health research project grants: a historical perspective on the " endangered species ". JAMA ,2007,297:2496-2501.
6陈香美,陈仆,蔡广研,吴杰,崔岩,张燕平,刘述文,汤力.麦考酚酸酯治疗IgA肾病的随访对照观察[J].中华医学杂志,2002,82(12):796-801. 被引量：93

中华肾脏病杂志

2006年第1期

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