Phen-铜(Ⅱ)-氨基酸配合物的合成、表征及其SOD活性

Synthesis, Characterization and SOD-like Activity of Phen-Cu(Ⅱ)-Amino Acid Complexes

合成了3个新的SOD模拟配合物:[Cu(Phen)(L-Gln)(H2O)]Cl·2H2O(1)、[Cu(Phen)(L-Ala)(H2O)]Cl·4H2O(2)、[Cu(Phen)(L-Thr)(H2O)]Cl·2H2O(3)[Phen(1,10-邻菲咯啉)、L-Gln(谷氨酰胺)、L-Ala(丙氨酸)、L-Thr(苏氨酸)]。用元素分析、摩尔电导、红外光谱、紫外-可见光谱对配合物进行了表征。用X-射线衍射对配合物[Cu(Phen)(L-Gln)(H2O)]Cl·2H2O的晶体结构进行了测定。用氯化硝基四氮唑蓝(NBT)光还原法对这3个配合物催化歧化超氧阴离子自由基(O2-·)的能力进行了测定。结果表明:这些配合物具有较高的SOD活性,催化速率常数KQ分别为1.58×107mol-1·L·s-1、5.65×107mol-1·L·s-1、0.83×107mol-1·L·s-1。

Three new complexes of Cu（Ⅱ） with phenanthroline and L-amino acicl [L-Glutamine（L-Gln）, L-Alanine （L-Ala）, L-Threonine（L-Thr）] were synthesized and characterized by elemental analysis, molar conductivity,infrared spectra, UV-Vis absorption spectra, and [Cu（Phen）（L-Gln）（H2O）]Cl·2H2O was characterized by X-ray diffraction method. The catalytic activities of the three complexes for disproportionation 02- of were determined by NBT method. The results show that the complexes have high SOD-like activities, and the KQ values of complexes 1, 2 and 3 are 1.58 × 10^7 mol^-1·L·s^-1, 5.65 × 10^7 mol^-1·L·s^-1, 0.83 × 10^7 mol^-1·L·s^-1 respectively. CCDC： 272495.