硝普钠预处理对高血压犬气管插管血流动力学的影响

Hemodynamic effect of sodium nitroprusside pretreatment for tracheal intubation in renal hypertensive dogs

目的:在肾动脉高血压犬模型上,评价硝普钠预处理后气管插管对高血压犬血流动力学影响.方法:肾动脉高血压杂种犬4条,经30 mg/kg戊巴比妥钠麻醉,建立血流动力学监测体系.用自身对照进行实验,4只犬不用硝普钠进行气管插管,连续观察血流动力学参数,测量显露声门、气管内置管和完成插管时的血压、心率.3 d后先自股静脉泵入硝普钠8μg/(kg.min),血压下降20%后同样条件下气管插管,观察各时间点血流动力学指标,两组数据进行配对t检验.结果:硝普钠预处理与未处理犬显露声门、气管内置管和完成插管时比较,血压升高,存在显著差异(P<0.05),而对心率无影响.结论:硝普钠预处理高血压犬在显露声门、气管内置管和完成插管时血管应激反应轻,可避免高血压犬血压的进一步上升.

AIM： To evaluate the preventive effect on the hemodynamic stress with the pretreatment of sodium nitroprusside followed by tracheal intubation in renal hypertensive dogs. METHODS： Four dogs with renal hypertension were enrolled in the auto-control experiment. The dogs were anesthetized by sodium pentobarbital injection （30 mg/kg） and then tracheal intubation was performed without sodium nitroprusside pretreatment. Three days later, the same dogs were given sodium nitroprusside （8 μg/kg ·min） via femoral vein before intubation. In the absence or presence of sodium nitroprusside pretreatment, their blood pressure and heart rate were measured at several time points, such as exposing glottis, inserting tube and completing intubation. The data under the two different conditions were compared by t test. RESULTS： There was significant difference in blood pressure with and without sodium nitroprusside at the time point of exposing glottis, inserting tube and completing intubation （ P 〈 0. 05 ） , while no difference was observed in heart rate. CONCLUSION： Sodium nitroprusside pretreatment can prevent the rise of blood pressure and reduce the hemodynamic stress in the process of tracheal intubation.