Midkine在食管鳞癌中的表达及其与微血管密度的关系

Expression and Significance of Midkine(MK)in Esophageal Squamous Cell Carcinoma and Correlation with Microvessel Density

目的研究MK在食管鳞癌中的表达及与肿瘤血管形成的关系。方法采用免疫组织化学SP法检测45例食管鳞癌组织中MK的表达,同时以CD34标记微血管内皮细胞测定微血管密度(mi-crovessel density,MVD)。结果45例食管鳞癌组织中MK阳性表达率为77.8%,MK阳性的食管鳞癌组织MVD为40.43±6.27,MK阴性的食管鳞癌组织MVD为31.34±3.89,两者有显著性差异(P<0.01)。结论MK在食管鳞癌中高表达并与血管形成有关。

Objective To study the expression of midkine in esophageal squamous cell carcinoma and the relation to angiogenesis. Methods A Immunohistochemical SP technique was used to detect the expression of MK in 45 cases who suffer from esophageal squamous cell carcinoma , Microvessel density（MVD） was also determined in endothelial as CD34. Results Positive MK Immunostaining was detected in 77. 8% of esophageal carcinoma,MVD was 40.43± 6.27 in esophageal carcinoma positive for MK while it was 31. 34±3.89 in esophageal carcinoma negative for MK （P〈0.01）. Conclusion Overexpression of Mk in esophageal carcinoma, and correlation with angiogenesis of esophageal carcinoma.