大肠癌中β-catenin表达及与COX-2、VEGF表达的关系

Expression of β-catenin in Human Colorectal Carcinoma and Its Relationship to Expression of COX-2 with VEGF

目的探讨大肠癌组织中β-catenin的异常表达的意义及与COX-2、VEGF表达的关系。方法应用免疫组化SP法检测78例大肠癌组织和15例癌旁正常粘膜组织中β-catenin、COX-2、VEGF的表达。结果β-catenin在15例正常组织均呈正常表达,而COX-2和VEGF均呈阴性。大肠癌中β-catenin异常表达率为75.6%,COX-2和VEGF阳性表达率分别为65.4%、70.5%。β-catenin异常表达与大肠癌的分化程度、转移和Dukes′分期显著相关(P<0.05)。COX-2、VEGF表达水平与大肠癌转移、Duke′s分期有统计相关性(P<0.05)。β-catenin异常表达与COX-2和VEGF的表达在大肠癌中均有显著的正相关性(P<0.05,r=0.278、0.419)。结论β-catenin在胞浆或胞核内的异常聚集以及COX-2和VEGF的过度表达共同参与大肠癌的进展。

Objective To investigate the replationship between the abnormal expression of ffcatenin and the high expression of COX-2 and VEGF and its significance. Methods The expression of ffcatenin and COX-2 and VEGF were detected in 78 cases of colorectal carcinoma and 15 cases of normal colorectal mucous tissues around the loci by immunohistochemical method. Results β-catenin was expressed normally in 15 cases of the normal colorectal mucous tissue,while COX-2 and VEGF were negative. The expression rate of COX-2 , VEGF was 65. 4%, 70. 5%, And the abnormal expression rate of β-catenin was 75.6% in the tissue of colorectal carcinoma. The abnormal expression rate of β-catenin was correlated with the extent of proliferation, Duke＇s stage and metastasis of lymph node（P〈0.05）. COX-2 and VEGF positive expression were correlation with the lymoh node metastasis and Duke＇s staging（P〈0. 05）. The abnormal expression of ffcatenin and the positive expression of COX2 and VEGF had a parallel relationship in colorectal carcinoma（P〈0. 05,r =0. 278,0. 419）. Conclusion β-catenin accumulation in the cytoplasm/nuclear and the high expression of COX-2 and VEGF have synergistic effect on the progression of colorectal carcinoma.