嘧啶核苷磷酸化酶与原发性肝癌预后的关系

The Expression of Pyrimidine Nucleoside Phosphorylase(PyNPase) in Primary Hepatocellular Carcinoma and Its Clinical Significances in Prognosis

目的初步探讨嘧啶核苷磷酸化酶在原发性肝癌中表达的临床预后意义。方法随机从我院外科2001年6月～2004年6月间185例原发性肝癌手术切除标本中随机抽取40例。术前均未经任何放化疗。使用SP免疫组化法分别检测肝癌细胞中PyNPase的表达。对所有病例的AFP水平，瘤体直径，门脉癌栓，转移复发率进行回顾性分析。结果①PyNPase的表达与肝癌Edmondson病理分级正相关。②PyNPase的表达与是否有PVTT、是否有肝内转移、淋巴结转移、肿瘤大小有关系，而与AFP水平、HbsAg阳性率无关。结论PyNPase在原发性肝癌组织中的表达水平除了对手术后的药物治疗有指导意义，其表达对肿瘤的预后有一定的提示意义。

Objective To investtgate the clinical significances in prognosis of the expression of Pyrimidine Nucleoside Phosphorylase（PyNPase） in primary hepatocellular carcinoma. Methods From Jun. 2001 to Jun. 2004, in 185 cases underwent hepatectomy for hepatocellular carcinoma,40 specimens were random ly selected as the experimental group, lnmunohistochemical staining had been used to detect the expression of PyNPase. Results ① There shows significant positive correlation between expression of PyNPase and the Edmondson＇s histological classification of HCC. ② There shows significant correlation between the expression of PyNPase and the existence of PVTT, LN metastasis, and diameter of the mass, but no correlation were found between the expression of PyNPase and the level of AFP and infective rate of hepatitis B. Conclusion The expression of PyNPase suggests the chemotherapeutic sensitive trend and the pronosis of HCC.