利用MCM2检测细胞的增殖性在大肠肿瘤诊断中的应用

Using MCM2 as A Novel Cell Replication Marker in Diagnosing Colorectal Carcinoma

目的了解细胞增殖标记物微小染色体支持蛋白2(minichromosomemaintenanceprotein2,MCM2)在大肠肿瘤诊断中的应用现状。方法复习国内、外的文献并加以综述。结果MCM2在肿瘤研究中可作为评估其细胞分化发育异常和突变的指标,细致地分析MCM2在不同大肠细胞突变阶段的表达有助于早期监测大肠细胞的突变。结论MCM2作为一个相对敏感而特异性的细胞增殖标记物,有望为早期临床检测大肠癌提供一种新的指标,从而有助于早期诊断大肠癌,提高患者的治愈率。

Objective To study the current research status of minichromosome maintenance protein 2 （MCM2）, the cell cycle proliferation marker, in the diagnosis of colorectal carcinoma. Methods Literatures about the application of MCM2 in the study of colorectal carcinoma were collected and reviewed. Results MCM2, as a marker of cell dysplasia and malignancy, was usually used in the study of carcinoma. The study on expression of MCM2 in the cell of colorectum in different proliferational stage might help to screen colorectal carcinoma as early as possible. Conclusion As a relatively specific and sensitive marker of cell proliferation, MCM2 might become a promising mark for diagnosing colorectal carcinoma in the early stage.