染色质与真核基因调控

Chromatin and the Regulation of Eukaryotic Genes

概括地介绍了染色质在真核基因调控中的关键作用,讨论了从核小体核心组蛋白的修饰、染色质重塑、DNA甲基化和siRNA等方面对染色质高级结构的阻遏或活化状态的调控及其机制。相关内容可为阐明多种生理过程和疾病发生的机理提供新思路,并为疾病的防治提供新靶点。

Recent advances on the role of chromatin in regulating eukaryotie briefly introduced in this review. Histone modifications, chromatin remodeling, DNA methylation and siRNA are discussed in context of chromatin structure-function relationship. Research achievements on chromatin function sheds lights on novel mechanisms in physiological or pathological phenomena that implicate candicates in future disease prevention and therapeutic targeting.