内质网应激反应基因表达调控的多样性

Diversity in Gene Expression Regulation of Endoplasmic Reticulum Stress Response

内质网通过激活未折叠蛋白反应(unfolded protein response,UPR),包括蛋白合成暂停、内质网分子伴侣和折叠酶等蛋白表达上调、诱导内质网相关性降解(ER-associated degradation,ERAD),以至细胞功能不能恢复,最后诱导内质网相关性细胞凋亡,清除受损细胞,保护机体生存。所有这些内质网相关反应都是各种应激信号刺激内质网,引起多种内质网应激基因表达的结果。转录、翻译以及翻译后加工各个环节对内质网应激时基因的表达产生调控,且方式各不相同。

Endoplasmic reticulum （ER） activates the unfolded protein response, including translation attenuation, up-regulation of ER chaperones and folding enzymes, and inducement of ER-associated degradation. Finally, apoptosis is induced when functions of the ER are severely impaired, to protect the organism by eliminating the damaged cells. All these events are results of expression of endoplasmic reticulum stress genes, in response to various stresses. Transcription, translation and post-translational processing and modification contribute to the regulation of endoplasmic reticulum stress response genes （ERSRGs） expression and the manners vary with different processes.