CD200分子及其受体的研究进展

Advances in the Research of CD200 and Its Receptors

CD200在人类和啮齿类动物均有表达，广泛分布于血管内皮细胞，淋巴细胞，神经元等。CD200受体有hCD200R1～R2和mCD200R1～R4等，表达于髓系细胞。应用可溶性分子CD200Fc、抗CD200R抗体和CD200^-/-转基因模型进行的研究表明，CD200在小鼠肾和皮肤移植排斥反应、胶原诱导性关节炎、实验性自身免疫性脑脊髓膜炎、实验性自身免疫性葡萄膜视网膜炎等自身免疫性疾病和自发性流产等病理生理过程中都发挥抑制作用。CD200与CD200Rs结合后，通过胞内NPXY序列或跨膜区与信号衔接分子结合产生效应．分子机制不明。

CD200 and its receptors CD200Rs belong to a group of leukocyte IgSF glycoproteins. CD200 expresses on a broad range of tissues including lymphoid cells, neurons, and endothelia, while CD2OORs only expresses in myeloid lineage in human and rodents. The family of CD20ORs includes hCD200R1 - R2 and mCD200R1 - R4. Evidence in a variety of rodent models using a chimeric molecule CD20OFc, anti-CD200R antibody and CD200-deficient mice suggests a key role for CD200/CD200R interactions in the regulation of acquired immunity： transplant rejection, fetal loss and autoimmune diseases, such as collagen-induced arthritis, experimental autoimmune uveoretinitis and experimental autoimmune encephalomyelitis. The molecular mechanism of CD200R inhibition of myeloid cell activation remains unknown.