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临床蛋白质组学——蛋白质组学在临床研究中的应用 被引量:7

Clinical Proteomics: The Application of Proteomicsin The Research of Clinical Medicine
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摘要 临床蛋白质组学是将蛋白质组学技术应用于临床医学研究,它主要围绕疾病的预防、早期诊断和治疗等方面开展研究,其中,恶性肿瘤是临床蛋白质组学研究的一个重点研究对象.由于肿瘤生物标志物对早期诊断具有重要价值,所以临床蛋白质组学的主要目标之一是寻找合适的肿瘤生物标志物,多分子生物标志物已成为寻找肿瘤生物标志物的一个研究趋势.简要介绍了临床蛋白质组学的基本概念,实验设计,临床样本收集与预处理以及蛋白质组学技术在临床研究中的应用与进展. Clinical proteomics is the application of proteomics in clinical medicine, which focuses on the prevention, diagnosis and therapy of disease. Cancer has been the primary research object in clinical proteomics. Because biomarker is invaluable in early diagnosis of cancer, one of the central goals in clinical proteomics is to discover appropriate biomarker and the interest shifts to looking for multi-biomarkers combined. Study design, sample collection and pre-process in clinical proteomics and the application and progress of clinical proteomics technology have been introduced.
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2006年第1期5-9,共5页 Progress In Biochemistry and Biophysics
基金 国家重点基础研究发展计划(973)(2001CB510208) 国家自然科学基金(30240056 30370642) 教育部跨世纪优秀人才培养计划基金(教技函[2002]48)资助项目 湖南省重点科研项目(025SY2001-1) 湖南省卫生厅重点科研项目(Z02-4)~~
关键词 蛋白质组学 临床蛋白质组学 肿瘤生物标志物 proteomics, clinical proteomics, cancer biomarker
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参考文献27

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同被引文献115

  • 1胡跃,张苏展,余捷凯,刘建,郑树,胡汛.血清蛋白质组图谱和人工神经网络软件在乳腺癌诊断中的应用[J].癌症,2005,24(1):67-71. 被引量:13
  • 2张宝林,范保星,贾向旭,苑晓玲,冯怡,彭善云,马良,刘又宁.与内皮抑制素相互作用的蛋白及其抑制血管生成作用的分子机制[J].中国临床康复,2005,9(38):23-25. 被引量:1
  • 3许洋.蛋白质指纹图谱技术在实验诊断与临床医学中的研究进展[J].基础医学与临床,2007,27(2):134-142. 被引量:36
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  • 10Sabounchi-Schutt F, Astrom J. Hellman U, et al. Changes in bronchoalveolar lavage fluid proteins in sarcoidosis:a proteomics approach. Eur Respir J,2003,21:414-420.

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