复方丹参注射液对汞中毒家兔不同组织脂质过氧化物的研究

EFFECT OF SALVIA MILTIORRHIZA ON LIPID PEROXIDES CONTENT IN THE TISSUES OF KIDNEY, LUNG, ILVER AND SPLEEN OF ACUTE MERCURILILSM RABBITS

通过皮下注射氯化高汞溶液造成家兔急性汞中毒模型。采用硫代巴比妥酸比色法测定肾皮质、肺、肝脾组织过氧化脂质（ＬＰＯ）含量，观察复方丹参注射液对其含量的影响，并同时测定了血尿素氮（ＢＵＮ）的动态变化。结果表明：急性汞中毒家兔上述组织ＬＰＯ明显高于对照组（Ｐ＜０．０１），ＢＵＮ也呈进行性升高。应用复方丹参注射液治疗后，其组织ＬＰＯ含量较汞中毒组明显下降（Ｐ＜０．０１）。ＢＵＮ水平也有所回降（Ｐ＜０．０１）。提示复方丹参注射液能降低急性汞中毒家兔肾、肺、脾、肝组织ＬＰＯ水平，减轻汞的致毒效力，特别是对肾脏的毒性作用。

An acute mercurialism model was established on rabbits by hypodermic injection of HgCl2.thiobarbituric acid colormietry was used to observe the effect of the compound injection of salvia miltiorrhiza,a chinese herbal medicine preperation, on lipid peroxides(LPO) content in the tissues of kidney, lung, liver, and spleen,and to observe that change of blood urine nitrogen(BUN). Results showed that LPO content in the tissues of the animal with acute hydrargyria was remarkably higher than that of the control group(p<0.01), and BUN concentration rose increasly. But the LPO content decrease significantly(p<0.01), and urea comcentration also showed some decrease after the compound injection of salvia miltiorrhiza had been given. These results suggest that the compound in jection can lower the LPO level in acute mercurialism tissues, and therefore that can alleviate the toxity of mercury, especially to the kidney.