代谢综合征患者的血清瘦素

Leptin in Patients with Metabolic Syndrome

目的观察代谢综合征(MS)患者血清瘦素水平,探讨其与肥胖、糖脂代谢,血压的关系以及瘦素在代谢综合征发病中的作用。方法选取MS患者77例,非MS患者100例,测定瘦素水平并分析其与血压、血糖、血脂及体重指数(BMI),腰围(WC)的相关性。结果代谢综合征组瘦素水平(12.8±4.0)ng/mL明显高于非代谢综合征组(7.7±3.0)ng/mL,瘦素水平随代谢异常组合个数增多而增加,血清瘦素浓度与性别、BMI、WC、血糖、收缩压、舒张压、总胆固醇、甘油三酯呈显著正相关。经多元逐步回归分析,血清瘦素浓度的影响因素为:性别、BMI、WC、血糖和甘油三酯。结论代谢综合征患者血清瘦素水平明显增高,且与性别、体重指数、血脂、血糖相关,瘦素与代谢综合征的诸多指标高度相关,提示高瘦素血症可能是代谢综合征的又一重要组成成分,代谢综合征患者存在瘦素抵抗并可能在代谢综合征发病中扮演重要角色。

Objective To study the role of leptin in MS and the association of leptin with obesity, metabolism of glucose, lipid and blood pressure. Methods Seventy-seven MS subjects and one hundred non-MS subjects as controls were recruited. The height, weight and waist circumference were measured, body mass index （BMI） was calculated. Systolic blood pressure（SBP） and diastolic blood pressure（DBP） were mearsured 3 times and averaged. Fasting blood glucose, plasma lipid and leptin were determined. Results The concentration of leptin in patients of MS is significantly higher than those of the non-MS. Serum level of leptin increased with the number of MS components. Linear correlation analysis indicate that leptin is significantly correlated with sex, age, BMI, WC, FBG, SBP, DBP, TC and TG. Multiple linear stepwise regression analysis reveals that leptin was related to sex, BMI, WC, FBG and TG. Conclusion The leptin level in MS group is significantly higher than that in non-MS group, suggesting Leptin resistance was found in MS. Serum level of leptin is related to sex, WC, BMI, TG and FBG. Leptin resistance may play an important role in the prevalence and progression of MS.