摘要
目的探讨血浆致动脉粥样硬化指数(AIP)与2型糖尿病(T2DM)患者大血管病变的关系。方法选择90例2型糖尿病患者与20例正常对照者,2型糖尿病患者按有无大血管并发症分成两组测量身高、体重,计算体重指数(BMI),测量血压、血脂,计算AIP(指TG/HDL-C比值的对数值),并进行统计学处理。结果与正常对照组比较,T2DM组呈现出TG升高,HDL-C降低,AIP值明显升高,其中,AIP值变化最明显(P<0·001);T2DM组中,有大血管并发症与无大血管并发症相比,大血管并发症组BMI、TG、TC、HDL-C、LDL-C、AIP差异有显著性(P<0·05),其中,AIP值差异最显著(P<0·001)。结论AIP间接反映LDL-C颗粒直径的大小,可作为2型糖尿病患者发生大血管并发症危险性的一个指标。
Objective To investigate the relationship between atherogenic index of plasma and cardiovascular disease with type 2 diabetes. Methods Ninty type 2 diabetic patients and twenty healthy subjects were recruited. The patient with T2DM were divided into two groups based on with or without cardiovascular complications. Atherogenic index was defined as the Log value of TG/HDL-C ratio. Results In T2DM group plasma triglyceride （TG） and AIP were significantly higher than those in control group, and HDL-C was significantly lower. In the cohort of diabetic subjects, the value of BMI, TG, TC, LDL- C, AIP in patients complicated cardiovascular disease were significantly higher than those without complications. Conclusion AIP value, an indirect indicator of LDL particle size may serve as an risk marker for cardiovascular disease in patients of T2DM.
出处
《高血压杂志》
CAS
CSCD
北大核心
2006年第1期43-45,共3页
Chinese Journal of Hypertension
关键词
血浆致动脉粥样硬化指数
甘油三酯
高密度脂蛋白胆固醇
低密度脂蛋白胆固醇
2型糖尿病
Atherogenic index of plasma
Triglyceride（TG）
High density lipoprotein-cholesterol{ HDL-C}
Low density lipoprotein-cholesterol（ LDL-C）
Type 2 diabetes
