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表皮松解性掌跖角化病1例 被引量:1

A case report of epidermolytic palmoplantar keratoderma
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摘要 报告1例表皮松解性掌跖角化病。患者女,26岁。双侧掌跖角化20余年。皮肤科检查见双侧掌跖对称性角化性斑块。皮损组织病理检查示表皮角化过度,颗粒层增厚,棘层及颗粒层中有较多裂隙,裂隙处细胞界限不清,由淡染物质或透明角质颗粒组成。组织病理改变符合表皮松解性掌跖角化病诊断。采用阿维A治疗后皮损明显改善。 A case of epidermolytic palmoplantar keratoderma is reported. A 26-year-old female presented with keratotic plaque on her palms and soles. The diagnosis of epidermolytic palmoplantar keratoderma was confirmed by histopathology. The disease was significantly improved by using acitretin.
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2006年第2期98-99,共2页 Journal of Clinical Dermatology
关键词 掌跖角化病 表皮松解性 palmoplantar keratoderma, epidermolytic
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  • 1Reis A, Kuster W, Eckardt R, et al. Mapping of a gene for epidermolytic palmoplantar keratoderma to the region for the acidie keratin gene cluster at 17q12-q21[J].Hum Genet,1992,90(1-2):113-116.
  • 2Bale SJ. DiGiovanna JJ. Genetic approaches to understanding the keratinpathies[J]. Adv Dermatol,1997,12:99-113.
  • 3Terron-Kwiatkowski A, Paller AS. Compto J ,et al. Two cases of primarily palmoplantar keratoderma associated with novel mutations in keratin I[J].J Invest Dermatol,2002,119(4):966-971.

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