补骨脂素长波紫外线和窄谱中波紫外线治疗寻常性银屑病临床疗效观察

Analysis of clinical efficacy of PUVA and narrow band ultraviolet B in the treatment of psoriasis vulgaris

目的:观察补骨脂素长波紫外线(PUVA)和窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的临床疗效及其影响因素。方法:分别采用PUVA和311nmNB-UVB照射治疗146例寻常性银屑病患者,并以银屑病面积和严重度指数(PASI)评价疗效,分析照射剂量等对疗效和复发的影响。结果:NB-UVB治疗寻常性银屑病的疗效与PUVA相当,NB-UVB组患者的治疗时间明显短于PUVA组,NB-UVB组患者1年内复发率高于PUVA组。结论:NB-UVB治疗寻常性银屑病与PUVA相比,不良反应较少,起效较快。

Objective： To investigate the efficacy and affecting factors of PUVA and narrow band ultraviolet B （NB-UVB） in the treatment of patients with psoriasis vulgaris. Methods： A total of 146 psoriatic patients were treated by PUVA therapy or 311 nm NB-UVB radiation. The efficacy was evaluated by psoriasis area and severity index （PASI）, and impacts of irradiation dose and relapse on the efficacy were also analyzed. Results： The efficacy of PUVA was comparable with that of NB-UVB. The treatment time was significantly shorter in NB-UVB group,but the relapse rate of PUVA group was higher within one year. Conclusions： Compared with PUVA therapy the treatment of NB-UVB is more safe for psoriasis vulgaris, and the remission duration is shorter.