308nm单频准分子光治疗寻常性银屑病和掌跖银屑病临床疗效观察

Analysis of clinical efficacy of phototherapy with MEL 308 nm in the treatment of psoriasis vulgaris and palmoplantar psoriasis

目的:评估308nm单频准分子光局部照射治疗寻常性银屑病和掌跖银屑病的临床疗效及安全性。方法:采用单频准分子光局部照射治疗35例寻常性银屑病和15例掌跖银屑病患者皮损,每周照射1次或2次,每2周评估疗效1次,并记录不良反应。结果:30例寻常性银屑病患者经16次照射,有效率达70%,慢性斑块型疗效较好。15例掌跖银屑病患者经25次照射,有效率为53.3%。单频准分子光局部照射主要不良反应为瘙痒,局部出现红斑,偶有水疱。结论:308nm单频准分子光局部照射治疗寻常性银屑病和掌跖银屑病见效快,疗程短,且不良反应少。

Objective： To evaluate the efficacy and safety of monochromatic excimer light （MEL） 308 nm in the treatment of psoriasis vulgaris and palmoplantar psoriasis. Methods： Thirty-five patients with psoriasis vulgaris and fifteen patients with palmoplantar psoriasis were recruited in the study. All patients were treated with MEL 308 nm therapy once or twice per week. The therapeutic effects and adverse effects were recorded. Results： After 16 times of treatment, patients with psoriasis vulgaris showed 70% improvement. Patients with chronic plaque got better improvement. After 25 times of treatment, patients with palmoplantar psoriasis got 53.3% improvement. The main side-effects included itching, erythema or blister. Conclusions： MEL 308 nm therapy was effective in the treatment of psoriasis vulgaris and palmoplantar psoriasis, without obvious adverse effects.