肾移植患者急性排斥反应与sCD30的相关性

Evaluation of pre-and posttransplant soluble CD30 for predicting acute renal allograft rejection

目的研究检测肾移植患者手术前后血清溶解性CD30(sCD30)水平的临床意义。方法采用酶联免疫吸附剂测定法(ELISA)检测69例肾移植患者术前及术后sCD30的水平,并分析sCD30与肾移植受者术后急性排斥发生的关系。结果术前sCD30阳性患者11例,其中有6例发生急性排斥,sCD30阴性患者58例,发生急性排斥5例。两组相比排斥反应发生率差异有统计学意义(P<0.01)。术后5dsCD30在发生排斥患者组中的水平与对照组间差异有统计学意义(P<0.05),而术后1、3d水平两组间差异无统计学意义(P>0.05)。结论肾移植手术前后监测sCD30水平,特别是术前及术后第5天左右时的检测水平,对于评估和预测急性排斥反应发生的可能性,具有重要的参考价值。

Objective To evaluate the relationship between the level of pre- and posttransplant soluble CD30 （sCD30） and the occurrence of acute renal allograft rejection. Methods The level of pre- and posttransplant sCD30 in the serum from 69 recipients （PRA〈 10 % ） was detected by enzyme-linked immunosorbnent assay （ELISA）. Results In group of positive sCD30 （ n = 11 ）, acute rejection occurred in 6 patients. In group of negative sCD30 （ n = 58）, acute rejection occurred only in 5 patients. There was a significant difference between two groups （P〈 0.01）. On the day 5 after transplantation, there was significant difference in sCD30 between acute allograft rejection group and control group （P 〈 0.05）. Conclusion The level of pre- and posttransplant sCD30, especially detected pretransplant and on the posttransplant day 5, is of important value for predicting acute renal allograft rejection.