乳头状汗管囊腺瘤临床及病理分析

Clinical and Histopathologic study of syringocystadenoma papilliferum

目的:研究乳头状汗管囊腺瘤的临床及组织病理特点。方法:回顾性分析研究我院1992～2005年共治疗的5例乳头状汗管囊腺瘤的临床病理资料。结果:5例患者均在20岁以前发病,男女比例1:4,主要发生于头面部。临床表现为单发或两个绿豆至蚕豆大小半球形结节或由丘疹融合而成的斑块;组织病理可见自表皮向下的多个囊状扩大凹陷,上部衬以复层鳞状上皮,下部有多个乳头状突起延伸至凹陷的腔内。乳头状突起及凹陷的下部衬以由内侧的高柱状细胞和外层的立方细胞组成的腺上皮,可见顶浆分泌。结论:乳头状汗管囊腺瘤是一种少见的大汗腺良性肿瘤,临床表现多样,易和皮脂腺痣等伴发,极易误诊。

Objective To study the clinical and histopathologic characteristics of syringocystadenoma papilliferum, the rare benign neoplasm of apocrine sweat glands. Methods We reviewed and studied the clinical and histopathologic information of five cases with syringocystadenoma papilliferum retrospectively,which were reported by the dermatology department of Southwest Hospital from 1992 to 2005. Results All of them occurred younger than 20 years old. The ratio of male to female was 1 to 4. Scalp and face were the main locations and the lesion of only one case occurred on the thigh.Clinically,the lesions of the skin manifested one or two hemispheroid nodules or plaques consisted of papules.Microscopically,the distinctive features were the duct-like structures and cystic spaces into which papillary projections of various sizes lined with two epithelial cell layers protruded.Apocrine appeared in some areas. Conclusion Syringocystadenoma papilliferum is a rare benign tumor of apocrine sweat glands.It shows a diversified clinical characteristics and it often ocuurs with sebaceous naevus and is often misdiagnosed.