椎基底动脉供血不足患者的血小板变化

Change of platelets in patients with vertebrobasilar arterial insufficiency

目的:对椎基底动脉供血不足患者血小板的数量、平均血小板体积、血小板压积、血小板宽度进行分析,探讨椎基底动脉供血不足患者血液参数改变及其意义。方法:选择2001-01/2004-03中南大学湘雅医院和白云区中医院收治住院患者127例,其中椎基底动脉供血不足组45例,男25例,女20例,年龄33～82岁;脑梗死组42例,男22例,女20例,年龄33～87岁;脑出血组40例,男20例,女20例,年龄32～81岁,以上患者发病均在3d内。健康对照组30例,男16例,女14例,年龄30～80岁。对椎基底动脉供血不足患者血小板的血小板体积、血小板压积、血小板宽度值进行统计分析。结果:157例被测试者均进入结果分析。①椎基底动脉供血不足组、脑梗死组、脑出血与对照组相比,血小板的数量下降、平均血小板体积增大,统计学上差异均有显著性(P<0.01)。②脑梗死、脑出血组间血小板的数量、平均血小板体积统计学上差异无显著性(P>0.05),但椎基底动脉供血不足组较脑梗死、脑出血组有统计学上差异[血小板数量:(151.12±70.85)×109,(210.07±70.45)×109,(201.53±96.76)×109,P<0.01;平均血小板体积:(13.07±1.82)fl,(9.40±1.76)fl,(9.51±1.35)fl,P<0.01]。③椎基底动脉供血不足组与脑梗死、脑出血组相比,血红蛋白、红细胞数、血小板压积、血小板宽度统计学上差异均无显著性(P>0.05)。④椎基底动脉供血不足、脑梗死与脑出血“血小板团块”比较,差别无显著性(P>0.05)。结论:心脑血管供血发生改变的疾病发病后早期均可出现平均血小板体积增大、血小板的数量下降现象,血小板自身外的某种因素,可能参与了平均血小板体积的增加与血小板的下降。

AIM： To analyze the number of platelets, mean platelet volume, plateletcrit and platelet distribution width in patients with vertebrobasilar arterial insufficiency, and investigate the changes of blood parameters and the significance in patients with vertebrobasilar arterial insufficiency. METHODS： Totally 127 inpatients were selected from the Baiyun District Hospital of Traditional Chinese Medicine and Xiangya Hospital of Central South University between January 2001 and March 2004, including 45 cases of vertebrobasilar arterial insufficiency. （25 males and 20 females aged 33-82 years）, 42 cases of cerebral infarction （20 males and 20 females aged 33-87 years）, 40 cases of cerebral hemorrhage （25 males and 20 females aged 32-81 years）, all the patients were within 3 days after attack. Another 30 cases （16 males and 14 females） were selected as the healthy control group. The mean platelet volume, plateletcrit and platelet distribution width in the patients with vertebrobasilar arterial insufficiency were statistically analyzed. RESULTS： All the 157 cases were involved in the analysis of results. ① As compared with the control group, the number of platelets was decreased and the mean platelet volume was enlarged in the vertebrobasilar arterial insufficiency group, cerebral infarction group and cerebral hemorrhage group, and there were significant differences （P 〈 0.01）. ②The number of platelets and mean platelet volume had no significant differences between the cerebral infarction group and cerebral hemorrhage group （P 〉 0.05）, which were significantly different from those in the vertebrobasilar arterial insufficiency group [number of platelets： （151.12±70.85）×10^9, （210.07±70.45）×10^9, （201.53±96.76）×10^9, P 〈 0.01; mean platelet volume： （13.07±1.82）fl, （9.40±1.76） fl, （9.51±1.35）fl, P 〈 0.01]. ③The hemoglobin, number of erythrocytes, plateletcrit and platelet distribution width in the vertebrobasilar arterial insufficiency group had no significant differences from those in the cerebral infarction group and cerebral hemorrhage group （P 〉 0.05）.④The ＂platelet ball＂had insignificant differences among the vertebrobasilar arterial insufficiency group, cerebral infarction group and cerebral hemorrhage group （P 〉 0.05）. CONCLUSION： The increase of mean platelet volume and decrease of the number of platelets appear at the early period after the .attack of disease of cardiovascular and cerebrovascular blood supple, in which certain factors outside platelet may participate.