药物相关性肥胖的研究进展

Progress in drug-induced obesity

抗精神病药物(APD)、抗抑郁药、抗癫痫药、类固醇和胰岛素等多种药物均可引起体重增加。前三者致体重增加的机制主要涉及多种神经递质受体介导的食欲增加、能量消耗减少、内分泌及代谢紊乱等多个方面,APD源性肥胖还与遗传基因缺陷有关;而类固醇和胰岛素致肥胖则与脂质代谢失常有关。药物相关性肥胖的防治包括宣传教育、选择合适的治疗方案、营养与行为疗法、加强锻炼,必要时应用一些减轻体重的药物等。

Many drugs can induce body weight gain, including antipsychotic, antidepressant drugs, antiepileptic, steroid, insulin, et al. Increased food appetite mediated by diverse neurotransmitter receptors, decreased energy expenditure, endocrinological and metabolic disorders, and so on may be involved in the mechanisms of the former three drugs-induced obesity. Moreover, antipsychotic-induced obesity is related to genetic deficiency. While steroid and insulin-induced obesity is concerned with lipid metabolic disorder. Drug-induced obesity must be prevented and treated by health education, appropriate treatment strategies, nutritional assistance and behavior therapy, physical exercise, and the utilization of some weight-reducing drugs when necessary.