摘要
目的:研究唾液腺多形性腺瘤恶变的临床病理特点。方法:回顾分析上海交通大学医学院附属第九人民医院口腔颌面外科1993年1月至2005年5月间唾液腺多形性腺瘤恶变病例的病理与临床资料。结果:108例唾液腺多形性腺瘤恶变病例,男68例,女40例,男女比为1.7∶1;年龄28～92岁,60～70岁最好发(29例),其次为50～60岁(22例)、70～80岁(20例)和40～50岁(19例)。发生于腮腺者68例,腭部20例,下颌下腺15例,其他部位包括唇、咽旁小唾液腺等。恶变成分主要为腺癌(26例),其次为肌上皮癌(19例),黏液表皮样癌(6例,包括低、中、高度恶性),腺样囊性癌(4例),其他有腺鳞癌、上皮-肌上皮癌、腺泡细胞癌、唾液腺导管癌、鳞癌等。5例发生颈部淋巴结转移,约占4.6%,其原发灶的恶变成分主要为腺癌。结论:唾液腺多形性腺瘤恶变多见于中老年男性,好发于腮腺,其次为下颌下腺和腭部,恶变成分多为腺癌和肌上皮癌;发生颈淋巴结转移者,恶变成分多为腺癌。
PURPOSE： To study the clinicopathologic features of malignancy of pleomorphic adenoma of the salivary gland. METHODS： 108 cases with malignancy of pleomorphic adenoma of the salivary gland were studied retrospectively in the Department of Oral and Maxillofacial Surgery, Ninth People＇s Hospital, School of Medicine, Shanghai Jiao Tong University from January 1993 to May 2005, including age, gender, site, pathologic features and clinical characteristics. RESULTS： The ratio of male to female was 1.7：1 （68 to 40）. 68 tumors were located in the parotid gland, 15 in the submandibular gland, 20 in the palate. Other sites included lip and parapharyngeal space. The malignant components were mainly the adenocarcinoma （26 cases）, followed by myoepithelial carcinoma （19 cases）, mucoepidermoid carcinoma （6 cases） and adenoid cystic carcinoma （4 cases）. Others were adenosquamous carcinoma, epithelio-myoepithelial carcinoma, acinic cell carcinoma, salivary duct carcinoma, squamous cell carcinoma, etc. Cervical lymph node metastases occurred in five cases （4.6%）, the malignant components of the primary tumor were mainly adenocarcinoma. CONCLUSION： Malignancy of pleomorphic adenoma of the salivary gland mainly occurred in old male and in the parotid gland, followed by the submandibular gland and the palate. The malignant components were mainly the adenocarcinoma and myoepithelial carcinoma. The malignant components of the primary tumors with cervical lymph node metastasis were mainly adenocarcinoma.
出处
《中国口腔颌面外科杂志》
CAS
2006年第1期30-33,共4页
China Journal of Oral and Maxillofacial Surgery
