检测子宫内膜异位症sICAM-1的临床意义

Soluble Intercellular Adhesion Molecule 1 in Serum and Peritoneal Fluid on Patients with Endometriosis

目的:研究子宫内膜异位症(简称内异症)患者血清和腹腔液中sICAM-1的水平,分析在这两种体液中sICAM-1水平的相关性以及sICAM-1与疾病期别的关系,探讨血清sICAM-1诊断内异症的临床价值。方法:采用酶联免疫吸附法检测30例内异症和30例非内异症患者血清和腹腔液中sICAM-1的水平。结果:①内异症组sI-CAM-1水平明显高于对照组(P<0.05);②内异症早期sICAM-1水平较晚期高(P<0.05);③血清和腹腔液中sICAM-1水平正相关(r=0.662,P<0.05);④血清sICAM-1检测内异症的敏感性和特异性分别是0.6和0.867。结论:sICAM-1可能参与了内异症的炎症过程,血清sICAM-1水平可作为内异症的早期诊断标志之一。

Objective： To investigate the levels of soluble intracellular adhesion molecule-1 （sICAM-1） in serum and peritoneal fluid（PF） of patients with or without endometriosis（EMs）, and to discuss the clinic significance of serum sICAM-1 in pelvic endometriosis. Methods： Levels of sICAM-1 were detected by an enzyme-linked immunoassay（ELISA）, and were compared between EMs and controls in serum and in PF. Results： ① Significantly higher sICAM-1 levels in serum and PF were observed in patients with EMs than those in controls （P〈0.05）;② Levels of sICAM-1 in serum and PF were significant differences between different stages of EMs, and in the early stage was higher than in the advanced stage （P〈0.05）;③ there was a correlation between levels of sICAM-1 in serum and PF （r=0. 662, P〈0.05） ;④ the sensitivity and specificity of serum sICAM- 1 in detecting peritoneal endometriosis were 0.6 and 0. 867, respectively. Conclusion： The sICAM-1 may participate in the inflammatory process in endometriosis. Serum concentrations of sICAM-1 seem to be the effective indicator for the diagnosis of endometriosis.