内分泌腺源性血管内皮生长因子与肿瘤相关性的研究进展

Endocrine glands-derived-vascular endothelial growth factor and tumor

回顾第一个组织特异性的血管生成因子:内分泌腺源性血管内皮生长因子(endocrine glands-derived-vascu lar endothelial growth factor,EG-VEGF)的研究与进展,发现EG-VEGF仅对有内分泌因素存在的靶器官、靶细胞产生作用,这些作用是通过与G-蛋白偶联受体结合激活蛋白激酶p44/42和磷脂酰肌醇3-激酶信号通路来发挥功能,以促进肿瘤血管形成、细胞扩增和转移。以EG-VEGF为靶位点的治疗方法可能为肿瘤治疗提供一个新的途径。

The review is focused on the development and recent research of the first tissue-specific angiogenic molecule, endocrine glandiderived vascular endothelial growth factor （ EG-VEGF）. It has been found that EG-VEGF only targeted on stcroidgenic endocrine organs or cells through G-protein coupled receptor, the phosphorylation of G-protein coupled receptor could activate mitogen-aetivated protein kinase p44/42 and phosphatidylinositol-3 kinase（PI3K） pathways signal transdution. There are many reports that believes MAPK and PI3K is involved in the regulation of proliferation, migration, survival of endothelial cells and tumor angiogenesis, so EG-VEGF may serve as a potential target for antiangiogenic therapy of cancer in the future.