胸腔内注入康赛宁治疗大量恶性胸水

Intrapleural Kanserin Injection for the Management of Serious Malignant Pleural Effusion

我科用康赛宁胸腔注入治疗大量恶性胸水病人9例。有效率66.7％(6/9),治疗有效者用药1～2次胸水被控制。治疗前患者体力<30分者治行有效率差。既往胸腔内注药无效者3例。顽固性胸水患者用康赛宁治疗无效。有33.3/(3/9)病人用药后出现一过性发热。1.1％(1/9)病人皮下注射部位出现红肿热痛硬结,无1例病人出现严重副反应。提示,康赛宁是治疗恶性胸水安全有效的药物。

Nine patients with serious malignant pleural effusion were treated with intrapleural injection of Kanserin, The effective rate was 66. 7%(6/9). Alter once or twice injections,the phural effusion was controlled in the effective patients. But the patients with Karnofsky<30 was poor. There was no effect in 3 patients who used to fail in intrapleural chemotherapy. The adverse effects of Kanserin administrated iutrapleurally were temporary mild fever (in 3 patients), red swelling at the injected site (in 1 patient). These results suggested that intrapleural administration of Kansevin is an effective and safe to treat serious malignant pleural effusion.