MSCT血管重建与巨块型肝癌双重化疗栓塞治疗的临床探讨

Preliminary Study on Multi-Slices CT Angiography and the Effect of Portal Vein and Arterial Dual-Chemoembolization on Large Primary Liver Cancer

目的:探讨肝癌的血供特点并进一步观察肝癌肝动脉、门静脉双重化疗栓塞治疗的不良反应。方法:选择22例巨块型原发性肝癌患者,随机分为两组,观察和比较两组治疗前后瘤体体积、白细胞和肝功能、生活质量变化。结果:MSCT(Multi-SlicesCT)肝癌肝动脉、门静脉血管重建成功率均为100%,可清楚显示Ⅳ～Ⅴ级肝动脉血管,结合肝动脉DSA造影,发现肝动脉供应肿瘤组织中心部分,门静脉包绕肿瘤,供应周边组织;两组有效率、治疗前后白细胞和肝功能变化、生活质量无显著差异(P>0.05)。结论:MSCT可用于肝癌血管重建;肝动脉、门静脉双重化疗栓塞治疗肝癌,未见明显不良反应。

Objective： To study the blood supply of primary liver cancer and evaluate the side effect of Portal Vein and Arterial Dual-Chemoembolization on it. Methods： Twenty-two subjects suffered large hepatocellular cancer were divided into two groups at random. The level of blood-routine, hepatic function, tumor size and of life quality were observed before and after the treatment. Results： The hepatic artery and portal vein were 100% successively reconstructed, Ⅳ-Ⅴ grade hepatic artery can be seen clearly. Combined with image from DSA, we find that hepatic artery surpply the center of the tumor,portal vein circumfuse the tumour; No significant differences were found in tumor sizes,the levels of WBC, TBil, ALT, life quality between the two groups （P〉0.05）. Conclusion： MSCT can be used to restrict the hepatic artery and portal vein for primary liver cancers and no significant side-effect has been found from the people who accepted portal vein and arterial dual-chemoembolization therapy.