^(18)F-FDG标准摄取值对非小细胞肺癌预后的影响

The Effect of Standardized Uptake Value of ^(18)F-FDG-PET on Prognosis of Non-small Cell Lung Cancer

目的:探讨18F-FDG标准摄取值(SUV)在判断非小细胞肺癌预后中的作用。方法:对122例非小细胞肺癌(NSCLC)经PET显像并计算出肺部肿瘤病灶感兴趣区(ROI)的SUV。结果:单变量分析结果显示,临床分期、身体状况及病理学类型间生存曲线有显著性差异(P<0.01);SUV>7的患者与SVU≤7患者间生存曲线差异有显著性(P<0.05),性别对生存期影响无显著性差异(P>0.05);COX多因素分析显示,总生存率与临床分期、身体状况、病理学类型及SUV大小(SUV>7和SVU≤7)密切相关,而性别对总的生存率无影响。结论:SUV值能够预测NSCLC的生物学恶性进程,并为临床治疗方案的选择和预后判断提供参考。

Objective： The study investigated the relationship between the standardized uptake value （SUV） and prognosis in patients with non-small cell lung cancer （NSCLC）. Methods： 122 patients confirmed NSCLC underwent LSF-FDG-positron emission tomography （PET） imaging. SUV was calculated in regions of interest （RIO） of pulmonary lesions on PET scans. Results： In the univariate analysis, performance status （P〈0.01）, stage （P〈0.01）, Tumor-cell type （P〈0.01）. SUV greater than 7 （P〈0.05）, were correlated with bad survival. However, there was no significant difference in gender （P〉 0.05）. Multivariate Cox model analysis indicated that the overall survival was significantly related to performance status （P〈0.01）, stage（P〈0.01）, Tumor-cell type（P〈0.01） and SUV （P〈0.05）. Conclusion： The results suggested that the lSF-FDG uptake in primary NSCLC with PET may play an important prognostic value and could be complementary to other well-identified factors in the decision on adjuvant treatment protocols.