复方蒿甲醚治疗海南省恶性疟33例的效果

THE CLINICAL EFFICACY OF ARTEMETHER COMPOUND IN TREATING 33 PATIENTS WITH FALCIPARUM MALARIA

1989年7～10月．在海南省抗药性恶性疟流行区试用复方蒿甲醇16片／3d疗程治疗恶性疟33例，均获治愈。平均退热时间和原虫无性体转阴时间分别为25．71±16．84h和28．957．87h；药后24h平均减虫为9724±4．28％；2例带配子体者在7d消失，余31例均不出现配子体；随访28d，未出现复燃；药后不出现毒、副反应．结果表明，复方蒿甲醚治疗恶性疟有速效、高效、低毒的优点。对配子体的形成似有抑制作用．在抗药性恶性疟流行区有扩大使用的价值。

From July to October in 1989, thirtythree dinical patients suffering from Falciparum malaria were treated with 16artemether compotind tgblets (each containing 120 mg benflumetolum and 20 mg artemether) for 2 days (4 tablets were administered) at oh. 8h, 24h and 48h respectively) in Baoguo and Baoxian state - run Farm Hospital, Dongfang county Both the farms were epidemic area of plasmodium falciparum in Hainan provonce. The medicine was Supplied by Institute of mictobiology and epidemiology, Military Medical Academy. The resylt showed that all patients had been cured clinically; the average time of fever Subsidence was 25- 71±16. 84h; the average time of asexual parasite clearence was 28. 95 ± 7. 87h; the average parasite reduction rate was 97. 24 ±4. 28％ at 24h after treatment; gametocytes in two patients disappeared on 5d and 7d afte r administration and no gametocyte appeared in other 31 cases after treatment.There was no recrudescence during a 28 -day - follow - up in 33 patients and the radical cure rate was 100%. There were no abnormal symptoms and signs of harmingheart, liver or kedneys during treatment.The results show that artemether compound is a quick - acting, high effective and low toxic medicine for Falcipartlm malaria (including part drug - resistant Falciparummalaria) the compound can be intensivelyused in areas where drug - resistant Falciparum malaria pvevails