血清基质金属蛋白酶9在急性胰腺炎严重程度早期评估中的价值

Value of MMP-9 in early severity assessment of acute pancreatitis.

目的探讨血清基质金属蛋白酶9（MMP9）定量测定对急性胰腺炎严重程度早期评估的价值。方法2004年1月～2005年6月住院治疗的急性胰腺炎（AP）患者24例，男11例，女13例，其中轻症急性胰腺炎（MAP）12例，男4例，女8例，平均年龄55．2岁；重症急性胰腺炎（SAP）12例，男7例，女5例，平均年龄43.6岁。所有患者均符合急性胰腺炎的诊断标准。选择12名军检健康者作为对照组，分别测定MAP、SAP患者及健康对照者的血清MMP-9浓度，并进行比较分析。结果入院后24h内SAP组血清MMP-9为（421．72=32．99）ng／ml，MAP组为（284．87±25.14）ng／ml，两者比较，差异显著（P〈0．001），MAP组与对照组间也存在显著差异（P〈0.001）。结论血清MMP-9水平在急性胰腺炎严重程度早期评估中具有一定价值。

Objective To investigate the value of MMP 9 in early severity assessment of acute pancreatitis. Methods Serum MMP-9 was determined quantitatively in 12 healthy persons, 12 patients with MAP, and 12 patients with SAP. APACHE- Ⅱ score 〉 8 was the criterion for diagnosis of SAP. Results The serum MMP-9 level in SAP group was significantly higher than that in MAP group （P 〈 0. 001） and that in control group（P 〈 0. 001）. The serum MMP 9 level in MAP group was significantly higher than that in control group （P 〈 0. 001）. Conclusions Serum MMP 9 level may prove to be valuable in early assessment of the severity of acute panereatitiss.