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苯那普利对自发性高血压大鼠肾脏Aquaporin2表达的影响 被引量：1

The effect of benazepril on the expression of aquaporin 2 in spontaneously hypertensive rat kidney
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摘要 目的:观察苯那普利对水孔蛋白2(AQP2)表达的影响。方法:雄性自发性高血压大鼠(SHR)16只,8周龄,体重200-300g,随机分成2组,每组8只,分别给予生理盐水(SHRctrl)、苯那普利(SHRben)灌胃。灌胃8周后断头取血,放免法测定血浆血管升压素(AVP)浓度。取肾脏近髓组织100mg,RT-PCR法检测大鼠肾脏AQP2mR-NA的表达,另取相应组织以免疫组化法检测AQP2的表达情况。结果:SHRctrl组和SHRben组大鼠药物干预前血压无明显差异,大鼠苯那普利灌胃8周后,血压明显下降,显著低于SHRctrl组大鼠血压[(112±17)mmHgvs(169±9)mmHg,P<0·05]。SHRben组大鼠肾脏AQP2mRNA(0·48±0·11vs0·72±0·17,P<0·05)、AQP2蛋白表达水平(0·47±0·09vs0·62±0·12,P<0·05)、血浆AVP浓度[(61·79±9·19)ng/Lvs(87·16±8·20)ng/L,P<0·05]均显著低于SHRctrl组。结论:苯那普利抑制SHR肾脏水孔蛋白2的高表达。
作者 黄继华 谢良地 许昌声 王华军
机构地区 福建医科大学附属第一医院福建省高血压研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2006年第2期388-390,共3页 Chinese Journal of Pathophysiology
基金 福建省科委资助项目(99A066)
关键词 水孔道蛋白类 血管升压素类 高血压 大鼠 苯那普利 Aquaporins Vasopressins Hypertension Rats Benazepril
分类号 R363 [医药卫生—病理学]
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参考文献6

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二级参考文献21

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共引文献15

同被引文献23

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引证文献1

中国病理生理杂志
2006年 第2期

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