石上柏联合放疗治疗鼻咽癌临床观察

Effect of Selaginella combined with radiotherapy on nasopharyngeal carcinoma

目的观察中药石上柏对晚期鼻咽癌的放射增敏作用。方法选择180例鼻咽癌患者随机分为A、B、C三组:A组患者仅接受单纯放疗;B组从放疗第1天开始,每日用石上柏30 g煎水50ml 口服,至放疗结束;C组在疗程的后半段开始服用石上柏。结果 B组或C组鼻咽原发灶的完全缓解率(CR)高于A组(P<0．05);B组或C组颈淋巴结CR率高于 A组(P<0．05)。B、C组的急性放射反应较A组轻,但差异无统计学意义。结论石上柏可能对晚期鼻咽癌有一定的放射增敏作用,并且不会增加正常组织的急性放射反应。

Objective To observe the Chinese herbal medicine Selaginella-induced radiosensitization of terminal nasopharyngeal carcinoma （NPC）. Methods Totally 180 patients with NPC were divided equally into 3 groups with the same radiotherapeutic potocols. The patients in group A received radiotherapy alone, those in group B were given daily Selaginella （30 g） prepared into 50 ml decoction during the entire course of radiotherapy, and those in group C had Selaginella 30 g daily in the late course of radiotherapy. Results The complete remission rate of nasopharyngeal primary lesions in groups B and C was significantly higher than that in group A, with also significantly higher complete remission rates of the cervical lymph nodes. The acute toxicity of the skin and mucous membrane was milder in the latter two groups, but the differences were not significant. Conclusion Selaginella may induce radiosensitization for terminal NPC and does not increase the acute toxicity of radiotherapy.