内皮素在火药爆炸烧伤大鼠心肌损害中作用

Effect of ET on myocardial injury of rats with complex burn caused by burn and gunpowder explosion

目的探讨内皮素(ET)在大鼠火药爆炸复合烧伤后心肌损伤中的作用。方法Wistar大鼠128只,随机分为正常对照组、烧伤组、爆炸伤组和复合伤组,分别致伤形成大鼠20%体表面积Ⅲ度烧伤、火药爆炸伤和两者复合伤。动态观察大鼠伤后1、3、6、12、24h血浆肌酸激酶心肌同工酶(CK-MB)及心肌组织ET含量变化。结果复合伤组较单因素致伤组大鼠血浆CK-MB升高明显,心肌组织ET含量呈类似变化,ET与CK-MB有相关性。结论火药爆炸复合烧伤对大鼠心肌的损害较单纯烧伤或爆炸伤更为严重,心肌ET含量的异常升高参与了复合伤后心肌损伤过程。

Objective To investigate the role of ET in myocardial injury of rats with complex burn caused by burn and gunpowder explosion. Methods 128 Wistar rats were randomly divided into 4 groups such as normal control group, simple burn group, explosion injury group, combined explosion and burn group （n = 40）. The rats were respectively injured to 20% BSA third degree burn, gunpowder explosion injury and complex injury with burn and ex- plosion. Dynamic observations were performed at 1,3,6,12 and 24 hours post injury on the changes of CK-MB in blood plasma and ET in cardiac muscle. Results Compared with simple burn group and explosion injury group, the complex burn group＇s ET in cardiac muscle and CK-MB in blood plasma elevated significantly,and the changes of ET activity was correlated to that of CK-MB. Conclusion The rat＇s myocardial injury is more obvious after complex burn and explosion than that of simple burn or simple explosion; the abnormal elevation of ET participates in the injury of cardiac muscle with complex burn caused by burn and gunpowder explosion.