呃逆与反流性食管炎的相关性探讨

Study on the correlation of hiccups with reflux esophagitis

目的探讨重度顽固性呃逆的发病原因。方法34例重度顽固性呃逆患者接受胃镜检查,回顾性研究呃逆与反流性食管炎的相关性及接受抑酸治疗的效果。结果胃镜发现本组呃逆患者食管炎伴球部溃疡10例,单纯性食管炎24例;按东京分类法:食管炎Ⅲ级14例,Ⅳ级20例。按重度食管炎用奥美拉唑胶囊20mg,2次/天,西沙比利10mg,3次/天,服药72h症状消失。结论重度呃逆可能是老年性中～重度反流性食管炎的首发或主要症状,PPi抑酸治疗为其有效的治疗方法。

Objective To investigate the cause of refractory hiccups. Method 34 patients with refractory hiccups admitted to our hospital from January 1996 to December 2003 were examined with gastroscopy. The correlation of hiccups with reflux esophagitis and the efficacy of omeprazole treatment were studied. Results 10 patients were proven endoscopically to have esophagitis and duodenal ulcer, and the other 24 were suffering from esophagitis. According to Tokyo classification, 14 cases were having grade Ⅲ esophagitis, and 20 were grade Ⅳ. All patients received omeprazole 20mg twice daily and cisapride 10mg thrice daily, and hiccups disappeared after 3 days. Conclusion Refractory hiccups may be the initial or primary symptom in moderate-severe esophagitis in aged people. Proton pump inhibitor therapy is effective in stopping refractory hiccup.