尿碱性成纤维细胞生长因子用于鉴别血管瘤和血管畸形的作用

Role of urinary basic fibroblast growth factor in differentiating hemangiomas from vascular malformation

目的探讨尿碱性成纤维细胞生长因子(bFGF)用于鉴别血管瘤和血管畸形、判断血管瘤是处于增生期或消退期以及动态监测血管瘤病程的作用。方法对133例患儿(包括增生期血管瘤69例、消退期血管瘤41例及血管畸形23例),应用酶联免疫吸附试验,检测尿bFGF浓度,并以无上述血管病变的唇腭裂11例患儿作为对照。结果增生期血管瘤患儿尿bFGF浓度显著高于消退期血管瘤、血管畸形患儿和对照患儿。前3者与对照患儿比较,差异均有统计学意义(P<0.01);后3者之间两两比较,差别均无统计学意义(P>0.05)。结论尿bFGF浓度有助于鉴别血管瘤和血管畸形;并可判断血管瘤是处于增生或消退期及动态监测血管瘤病程,可为分析血管瘤的发生机制提供依据。

Objective To investigate a novel method to differentiate hemangioma from vascular malformation, to stage hemangiomas and to monitor the efficacy of management for hemangioma. Methods The urinary basic fibroblast growth factor （ bFGF ） concentration of 144 cases （ including 69 cases of proliferating hemangiomas, 41 cases of involuting hemangiomas, 23 cases of vascular malformations and 11 negative controls ） was examined using enzyme linked immunosorbent assay （ELISA）. Results The differences of urinary bFGF concentration among proliferating hemangiomas, involuting hemangiomas, vascular malformations and negative control were all significant, while the differences between the latter three groups were not significant. Conclusions Our findings suggest that examination of urinary bFGF concentration using ELISA technique is helpful in differentiating hemangioma from vascular malformation, staging hemangiomas and dynamically monitoring the efficacy of treatment for hemangiomas. Our results probably shed new light on the potential pathogenesis of hemangiomas and vascular malformation.