氨基胍和维生素C对糖尿病大鼠血脂的影响

The effects of aminoguanidine and Vitamin C on blood lipid of streptozotocin-induced diabetes rats

目的观察氨基胍、维生素C对糖尿病大鼠的血脂的影响。方法利用链脲佐菌素腹腔注射法诱导建立1型糖尿病大鼠模型,将实验用50只SD大鼠随机分为正常对照组、糖尿病组、维生素C治疗组、氨基胍治疗组、维生素C和氨基胍联合治疗组。治疗16周。观察治疗期间及治疗后大鼠的一般状况、血糖(BS)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、糖化血红蛋白(HbA1 c)、糖化低密度脂蛋白(G-LDL)。结果造模4组大鼠均出现血脂异常;氨基胍、维生素C对血糖无影响,但能改善基本状况,维生素C能降低糖尿病大鼠的甘油三酯、胆固醇、低密度脂蛋白、糖化血红蛋白、糖化低密度脂蛋白,升高高密度脂蛋白;两种药物联合用药具有协同作用。结论氨基胍、维生素C无降糖作用,但维生素C具有确切的调节血脂作用,联合用药有协同作用。

Objective To observe the effects of aminoguanidine and Vitamin C on lipid of streptozotocin-induced didbetic rats. Methods Diabetic nephropathy rats were induced by intraperitoneal injection of streptozotocin. Fifty Sprague-Dawley （SD） rats were randomly divided into normal control group, model group, Vitamin C group, aminoguanidine group and Vitamin C associated with aminoguanidine group. All the rats were treated for 16 weeks. During and after the treatment, the general state of the rats was observed and the levels of blood sugar, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, glycosylated hemoglobin, and glycated low density lipoprotein in different groups were detected. Results The rats in the four groups suffered diabetes mellitus and renal function lesion. Aminoguanidine and Vitamin C could improve the general state of the rats, but had no effect on the blood sugar. Vitamin C could decrease the levels of triglyceride, serum cholesterol, low density lipoprotein, glycosylated hemoglobin, and glycated low density lipoprotein, and increase the level of high density lipoprotein. There was a synergistic effect with the combination of the two drugs. Conclusion Aminoguanidine and Vitamin C have no effect in the decrease of blood sugar level but have a certain effect on regulating blood lipid. There is a synergistic effect with the combination of the two drugs.