富血小板血浆促进骨修复的理论研究与临床实践(英文)

Theoretical study and clinical practice of platelet-rich plasma in improving bone repair

目的:归纳总结富血小板血浆的发展、作用机制及目前还存在的问题,为富血小板血浆的临床应用提供参考。资料来源:应用计算机检索Medline1995-01/2005-06关于富血小板血浆对骨修复的作用的相关文献。检索词“platelet-richplasma,bone,re-pair”,同时应用计算机检索万方数据库1998-01/2005-06期间的上述相关文章,限定文章语言种类为中文,检索词“富血小板血浆,骨,修复”。资料选择:选择有关富血小板血浆和骨修复的中外研究文献;未排除非随机对照的研究文献。资料提炼:49篇关于富血小板血浆与骨修复的文献,其中40篇符合标准。排除的9篇文献是因为重复的同一研究。对剩余的40篇文献进行分类整理,予以综述。资料综合:富血小板血浆在1998年首先被应用于临床修复下颌骨缺损,在颌面缺损处植入自体骨与富血小板血浆的复合物,骨密度影像测定发现富血小板血浆组与单用自体骨的对照组相比,其骨成熟度是对照组的1.62～2.61倍。在随后的这些年里,富血小板血浆已经在很多医学领域被用来促进组织修复,其特点:安全,简便,廉价。但目前仍有一些问题有待进一步研究和解决。结论:富血小板血浆包含多种生长因子,且已被证明可促进骨组织和软组织的修复。富血小板血浆经离心自体血而制成,制作简单,安全。由于是自源性的,根本上排除了疾病传播及免疫排斥的可能。

OBJECTIVE： To review the development and mechanism of platelet-fich plasma （PRP） and the unsolved problems so as to provide reference for the clinical application of PRP. DATA SOURCES： Articles on effects of platelet-rich plasma on bone repair are searched from Medline between January 1995 and June 2005 on computer. The key words were platelet rich plasma, bone, and repair. Meanwhile, the same search was conducted to determine the correlated articles during January 1998 to June 2005 from Wanfang database with key words of platelet-rich plasma, bone and repair in Chinese. STUDY SELECTION： Literatures at home and abroad on the PRP and bone repair were chosen; Non-randomized controlled literatures were included. DATA EXTRACTION： Totally 40 out of 49 reports related to PRP and bone repair met the criteria. 9 reports were excluded due to the repeated same research. The rest 40 reports were sorted out and conducted literature review. DATA SYNTHESIS： Platelet-rich plasma was originally used in clinic to repair mandibular defect in 1998, by adding PRP to grafts with a radiographic maturation rate 1.62 to 2.16 times that of grafts without PRP. Up to now, PRP has been used in many medical areas to accelerate tissue healing due to its advantages of safety, simple, low-cost. But some problems still remain to be studied and solved. CONCLUSION： PRP includes many sorts of growth factors and has been proved to be beneficial to the maturation of both bone tissue and soft tissues. PRP is autologous and can be produced easily and safely from autologous blood, without the concerns of transmissions and immunological rejection of various diseases.